Photobiomodulation
Red and near-infrared light, cellular signaling, dose-response relationships and clinical translation.
Skin Optics Research Laboratory · Laval, Québec, Canada
RoseLab
Translational research at the intersection of photomedicine, photobiomodulation, skin optics and laser–tissue interactions.
About RoseLab
Understanding how light interacts with skin.
RoseLab Skin Optics Research Laboratory is a research laboratory in Laval, Québec, focused on the biological and clinical effects of light on human skin.
Our work connects optical parameters—including wavelength, irradiance, fluence and pulsing—with measurable biological responses, with the aim of improving the scientific basis and clinical translation of light-based dermatologic treatments.
Research focus
From photons to biological response.
Light dosimetry
Wavelength, irradiance, fluence, pulsing, treatment interval and optical delivery parameters.
Skin repair & pigmentation
Collagen metabolism, wound healing, scar modulation, photopreconditioning and post-inflammatory pigmentation.
Laser–tissue interactions
Clinical and translational investigation of laser dermatology and energy-based technologies.
Selected research
Selected publications.
A selection illustrating RoseLab’s longitudinal work in photobiomodulation, skin optics and translational laser dermatology.
2008
LED photoprevention: reduced MED response following multiple LED exposures
Lasers in Surgery and Medicine
2009
Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source
Journal of Investigative Dermatology
2010
Importance of pulsing illumination parameters in low-level-light therapy
Journal of Biomedical Optics
2018
Dual Effect of Photobiomodulation on Melasma
Journal of Clinical and Aesthetic Dermatology
2023
Low-Intensity Visible and Near-Infrared Light-Induced Cell Signaling Pathways in the Skin
Photobiomodulation, Photomedicine, and Laser Surgery
2024
Differential Nitric Oxide Responses in Primary Cultured Keratinocytes and Fibroblasts to Visible and Near-Infrared Light
Antioxidants
2025
Fully ablative CO₂ laser therapy for rhinophyma: long-term efficacy, safety and AI-assisted predictive modelling
Skin Health and Disease
People
Daniel Barolet, MD, FRCPC
Director, RoseLab Skin Optics Research Laboratory
Canadian dermatologist and clinician-researcher whose work focuses on laser dermatology, photomedicine and photobiomodulation. His publications span photopreconditioning, collagen biology, light dosimetry, pigmentation, cellular signaling and clinical laser applications.
Daniel Barolet is affiliated with the Dermatology Division, Department of Medicine, McGill University Health Centre / McGill University.
RoseLab Skin Optics Research Laboratory
Laval, Québec, Canada